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For other uses, see S-100 (disambiguation).

The S-100 bus or Altair bus, IEEE696-1983 (withdrawn), was an early computer bus designed in 1974 as a part of the Altair 8800, generally considered today to be the first microcomputer designed for hobbyists rather than end users. The S-100 bus was the first industry standard expansion bus for the microcomputer industry. S-100 computers, consisting of processor and peripheral cards, were produced by a number of manufacturers. The S-100 bus formed the basis for homebrew computers whose builders (e.g., the Homebrew Computer Club) implemented drivers for CP/M and MP/M. These S-100 microcomputers ran the gamut from hobbyist toy to small business workstation and were common in early home computers until the advent of the IBM PC (which some of them outperformed).

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