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This article is about multiple drug resistance in microorganisms. For multiple drug resistance in tumor/cancer cells, see antineoplastic resistance.

Multiple drug resistance (MDR), multi-drug resistance or multiresistance is a condition enabling disease-causing microorganisms (bacteria, viruses, fungi or parasites) to resist distinct antimicrobials, first and foremost antibiotics, but also antifungal drugs, antiviral medications, antiparasitic drugs, chemicals of a wide variety of structure and function targeted at eradicating the organism.

Recognizing different degrees of MDR, the terms extensively-drug resistant (XDR) and pandrug-resistant (PDR) have been introduced. The definitions were published in 2011 in a journal called "Clinical Microbiology and Infection" and are openly accessible

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