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The Great Plague (1665–66) was the last major epidemic of the bubonic plague to occur in the Kingdom of England (part of modern-day United Kingdom). It happened within the centuries-long time period of the Second Pandemic, an extended period of intermittent bubonic plague epidemics which began in Europe in 1347, the first year of the Black Death, an outbreak which included other forms such as pneumonic plague, and lasted until 1750.

The Great Plague killed an estimated 100,000 people, or almost 25% of London's population. Plague is caused by the Yersinia pestis bacterium, which is usually transmitted through the bite of an infected rat flea.

The 1664–66 epidemic was on a far smaller scale than the earlier Black Death pandemic; it was remembered afterwards as the "great" plague mainly because it was the last widespread outbreak of bubonic plague in England during the 400-year timespan of the Second Pandemic.

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