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"Basophil" redirects here. For the cells of the anterior pituitary, see anterior pituitary basophil.

Basophil granulocytes, mostly referred to as basophils, are the least common of the granulocytes, representing about 0.01% to 0.3% of circulating white blood cells. Standard Range is 0.0 - 2.0 % via differential blood count.

Basophils contain large cytoplasmic granules which obscure the cell nucleus under the microscope when stained. However, when unstained, the nucleus is visible and it usually has two lobes. The mast cell, another granulocyte, is similar in appearance and function. Both cell types store histamine, a chemical that is secreted by the cells when stimulated. However, they arise from different cell lines, and mast cells usually do not circulate in the blood stream, but instead are located in connective tissue. Like all circulating granulocytes, basophils can be recruited out of the blood into a tissue when needed.

The name comes from the fact that these leukocytes are basophilic, i.e., they are susceptible to staining by basic dyes, as shown in the picture.

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